The San Francisco JAMstack meetup is the largest of its kind, featuring presenters who are often authors of popular build tools like Webpack and Jekyll. The event focuses on modern web development topics such as the Jamstack, Static sites, and serverless technologies. Netlify, a platform for building fast and secure websites, hosts this meetup and provides resources for developers to learn about its features and best practices. The event aims to help attendees deliver web projects 10 times faster by leveraging the power of the Jamstack and Netlify's tools.