TensorFlow is an open-source machine learning library developed by Google, widely recognized for its ability to facilitate the training of deep neural networks with GPU-accelerated computation. The guide provides a comprehensive step-by-step approach to installing the latest version of TensorFlow with CUDA, cuDNN, and GPU support across different operating systems, including Windows, macOS, and Linux. It outlines prerequisite software and hardware requirements, installation steps, and testing procedures to ensure a successful setup. While Windows and Linux support GPU installations, macOS generally requires additional effort for GPU support due to its lack of native compatibility. By following this guide, users can optimize TensorFlow for high-performance computing, enabling efficient handling of deep learning tasks.