Advancing confidential computing and cross-border bioinformatics at the ELIXIR BioHackathon

The BioHackCloud project, a collaboration involving leading bioinformaticians and computational biologists from academia and industry, aims to advance the secure and responsible use of genomic data through a federated cloud platform based on the Global Alliance for Genomics and Health's (GA4GH) open framework. Enabled by Nebius AI Cloud and its partners, the project has made significant strides in safeguarding sensitive biomedical workflows with technologies like attested TLS (aTLS) and confidential computing, ensuring privacy and cross-cloud interoperability. Key achievements include a proof of concept for aTLS, which allows users to verify the trustworthiness of software in secure execution environments, and private LLM inference through an OpenAI-compatible API. The initiative also supports confidential task execution via ELIXIR TESK, a Kubernetes-native implementation for multi-cloud environments, and leverages Nebius' Slurm-on-Kubernetes for efficient GPU resource management. As part of the broader European Open Science Cloud (EOSC) and through efforts like the TRE Open Suite project, BioHackCloud aims to enhance privacy and security standards while enabling cross-border bioinformatics. Looking forward, the project plans to deepen its frameworks and showcase new attested TLS implementations during the 2025 ELIXIR BioHackathon, offering a sandbox for technological exploration in genomics, AI, and bioinformatics.

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