The Ops Guide to a Peaceful Thanksgiving focuses on the importance of maintaining a stable database infrastructure during the holiday season. To ensure peace of mind, it emphasizes the need for proper monitoring and alerts, deploying nodes across data centers to maintain availability, avoiding deploying a majority of nodes in a single data center, and having a backup/recovery system in place. By following these best practices, operations teams can minimize downtime and ensure that their database remains healthy and available during the holidays.