MongoDB and Node.js have gained significant industry validation as a powerful combination for real-time applications in the enterprise. eBay's use of Node.js with MongoDB for its "Talk" project is notable, and strong distribution offerings from companies like Strongloop are appealing to growing enterprise needs. The community enthusiasm around this stack is evident in the widespread adoption of Node.js by thousands of developers and the numerous user groups hosting presentations on the topic. Furthermore, the flexibility of MongoDB's data model and the scalability of Node.js make it a promising technology for handling large amounts of JSON data and performing I/O requests efficiently.