To create a Pub/Sub (Publish-Subscribe) application with MongoDB, developers can utilize the database's native features of Capped Collections and Tailable Cursors. This technique is suitable for applications that require alerts when new documents are inserted or modified in the database, such as real-time apps, notifications, messaging, or chat features. The `How to Create a Pub/Sub application with MongoDB` blog post provides detailed information and code samples to implement this approach, along with a screencast demonstration of the application built using this technique.