In the burgeoning API economy, commercializing APIs is vital for generating revenue, requiring a strategic approach and the right tools. Successful API monetization involves ensuring ease of discovery and interaction, robust documentation, and inclusion in major marketplaces to attract users. Moesif, an analytics-based monetization platform, offers solutions for diverse industries like web3, biotech, and healthtech by allowing businesses to bill based on specific parameters and metrics relevant to their verticals. API commercialization challenges include accurately quantifying usage, providing customer support, and ensuring scalability. Companies like BioLM and Symbl.ai utilize Moesif to efficiently track API usage and implement adaptable billing strategies, highlighting the importance of aligning API development with clear business objectives and detailed analytics.