Vertical text orientation in CSS can be challenging for cross-browser compatibility due to its relatively recent introduction and varying levels of browser support. While the CSS `text-orientation` property, which works with the `writing-mode` set to vertical, is supported by major browsers like Chrome, Firefox, Opera, and Safari, it is not supported by Microsoft Edge and Internet Explorer, necessitating fallbacks for these browsers. Alternative methods such as using CSS properties like `word-break`, `word-wrap`, or JavaScript can also achieve vertical text orientation, though these methods may involve trade-offs in practicality and aesthetics. Tools like LambdaTest facilitate cross-browser testing to ensure that text-orientation properties work as intended across different platforms. Despite the advances in CSS3 that address vertical text challenges, developers are advised to anticipate further changes in syntax and ensure compatibility through robust fallback strategies.