Debugging website issues can be a daunting task for developers, but adopting effective strategies can simplify the process. Common practices include focusing on syntax errors, which are more prevalent than logical errors, and ensuring all elements in the code are correctly placed. Developers are advised to "blackbox" scripts from libraries and frameworks, which are already tested and bug-free, to save time during debugging. Addressing cross-browser compatibility issues is crucial, and tools like LambdaTest can assist in testing HTML and CSS across different browsers. While minification of code enhances readability by removing unnecessary characters, it complicates debugging, though tools like Chrome's Pretty Print can help. Optimizing the development environment, such as disabling certain caching behaviors in Symfony, can prevent confusion during debugging. General tips include reproducing bugs, understanding stack traces, and seeking external advice when stuck. Celebrating debugging successes, no matter how small, is encouraged to maintain morale and improve efficiency.