Selenium Focus Element issues arise when automated test scripts interact with web elements not yet loaded in the Document Object Model (DOM) or when they are on another iFrame, tab, or window that is not in focus. These issues are common due to the asynchronous nature of web elements loading, often via AJAX. The text discusses various strategies to address these challenges, such as using the `switch_to().frame()` method to navigate between iFrames, handling multiple tabs by switching to the correct window using window handles, and dealing with onfocus() and onblur() callbacks by executing JavaScript through Selenium WebDriver. Additionally, WebDriverWait() is recommended for handling incomplete page loading to ensure the presence of web elements before interaction. The document also highlights the benefits of using cloud-based platforms like LambdaTest for automated cross-browser testing, which can enhance test efficiency and scalability, particularly through parallel testing, thereby mitigating Selenium Focus Element issues.