Nose2 is a Python test runner that extends the unittest framework by adding a rich plugin ecosystem to enhance functionality, particularly benefiting users familiar with unittest. As a successor to the older Nose, Nose2 improves upon its predecessor by offering a better plugin API, facilitating parameterized tests, organizing test fixtures, and enabling parallel testing through its multiprocess (mp) plugin. This makes Nose2 a robust choice for Selenium Python testing, allowing seamless integration with cloud-based Selenium Grids like LambdaTest, thus supporting scalable cross-browser testing. The tutorial provides detailed guidance on setting up and executing tests using Nose2, including installing necessary packages, utilizing fixtures, and generating reports, while emphasizing the framework's advantages in configuration management and plugin loading.