Resolving test failures is crucial for maintaining a reliable test system, especially with frameworks like Selenium and pytest. Debugging these failures often involves addressing issues such as dynamic web elements, synchronization, browser compatibility, and specific exceptions like TimeoutException or ElementNotInteractableException. Effective debugging practices include identifying flaky tests, managing test data, and employing strategies to handle dynamic content. Advanced techniques like remote debugging, analyzing network traffic, and using Selenium Grid for cross-browser testing can further enhance the debugging process. Best practices, such as implementing the Page Object Model (POM) and test retry mechanisms, contribute to robust and maintainable test automation. By employing these strategies, developers can efficiently pinpoint and resolve the root causes of test failures, ensuring a more reliable and effective testing process.