Ensuring mobile accessibility is vital for creating inclusive, user-friendly websites that cater to individuals with impairments, including visual, auditory, cognitive, and motor disabilities. This involves designing and developing sites and applications that are easily navigable on mobile devices, which have become indispensable in daily life. Key challenges include poor color contrast, lack of keyboard accessibility, and insufficient screen reader support. Best practices for overcoming these challenges include using responsive design, clear and legible fonts, alternative text for images, accessible color schemes, and ensuring compatibility with assistive technologies. Regular accessibility audits and testing across various devices can help maintain compliance with evolving guidelines and improve the user experience. By addressing these issues, businesses can enhance user trust, increase sales, and promote digital equality. Improving mobile accessibility not only benefits users with impairments but also bolsters business reach and reputation.