The guide discusses the process of running Selenium tests using the Internet Explorer (IE) Driver, despite IE's declining market share, highlighting its relevance in cross-browser testing due to its still significant user base. The text provides detailed instructions on setting up and configuring the Selenium Internet Explorer Driver across various programming languages, including Python, Java, C#, and PHP. It outlines specific configurations necessary for IE, such as setting browser zoom levels and adjusting Windows Registry entries, to facilitate automation testing. Furthermore, the text explores the execution of tests on both local and cloud-based Selenium Grids, with a focus on LambdaTest as a cloud solution. It addresses challenges such as compatibility settings and performance issues, offering insights into the technical nuances of conducting reliable automated tests on the IE browser.