The guide on CSS text orientation emphasizes the importance of adapting website text to accommodate various languages, enhancing accessibility and inclusivity for a diverse global audience. It explores CSS properties such as writing-mode and text-orientation, crucial for determining text direction and alignment, which can significantly impact readability, layout, and website responsiveness. The guide highlights the use of CSS text orientation in different contexts like responsive web design, localization for multilingual support, and maintaining content hierarchy. It also addresses browser compatibility, noting that while most browsers support these properties, some experimental values like sideways-lr have limited support, primarily in Firefox. The guide underscores the potential of CSS text orientation to improve the user experience by creating visually appealing and functionally robust web designs, while also cautioning against overuse in horizontal scripts like English to maintain readability.