In the comparison of CSS Grid and Bootstrap, both serve as critical tools for web developers in designing responsive and efficient layouts, but each has distinct applications and advantages. CSS Grid, inspired by print layouts, offers two-dimensional control over the placement of elements, allowing for precise organization across both rows and columns, which is ideal for static and symmetric designs. It excels in scenarios requiring complex layouts with overlapping or asymmetric content and benefits from its native CSS implementation, which can enhance loading speeds and reduce project complexity. Conversely, Bootstrap, built on a Flexbox-based grid system, provides a more flexible, one-dimensional layout control, which is excellent for creating responsive designs that adapt well to different screen sizes with predefined breakpoints. Although Bootstrap may require more markup, it simplifies the development of dynamic layouts with its twelve-column grid system and is favored for projects needing rapid development and flexibility. Both frameworks offer capabilities for ordering and aligning items, but CSS Grid is often preferred for projects demanding more control over layout precision, while Bootstrap is valued for its flexibility and ease of use in creating responsive designs.