As digital transformation drives networks to the cloud, cyberattacks have become more frequent and sophisticated, exposing the limitations of traditional security models like VPNs and perimeter-based firewalls. To address these challenges, Zero Trust security frameworks and microsegmentation emerge as effective solutions. Zero Trust requires continuous verification of entities accessing applications, safeguarding networks from inside threats, while microsegmentation divides networks into smaller segments to control data access and prevent unauthorized lateral movement. This combination reduces the attack surface and enhances security by allowing organizations to implement granular policies tailored to specific workloads. Despite the complexities and challenges associated with microsegmentation, such as visibility, policy management, and scalability, its integration within Zero Trust frameworks offers robust protection for hybrid and multi-cloud environments. Tools with features like unified policy management, dynamic segmentation, automation, and real-time traffic monitoring are essential for maximizing the benefits of microsegmentation.