The guide provides an in-depth exploration of strategies to secure Large Language Models (LLMs) against emerging threats, focusing on the OWASP LLM Top 10 vulnerabilities, such as injection attacks, data leaks, and model theft. With the rapid adoption of LLMs across industries, the guide emphasizes the necessity for AI developers, product managers, security leads, and compliance officers to implement robust security frameworks. It highlights real-world examples like the DeepQuery breach to illustrate risks, describes the unique challenges posed by LLMs compared to traditional web applications, and outlines defense strategies including input validation, encryption, access control, and regular security testing. The guide also covers compliance with evolving regulations like GDPR and CCPA, emphasizing the importance of building a secure AI ecosystem through principles like least privilege, role-based access control, and ethical AI guidelines. As LLMs become integral to business operations, securing them is vital to safeguarding an organization's financial health, reputation, and competitive edge.