Enterprises are increasingly investing in data mesh and API platform initiatives to enhance decision-making, foster innovation, and improve agility by productizing business domains as self-service digital assets. Both initiatives aim to shift from project-based to product-based thinking, placing business domains at the core of organizational design and promoting decentralized, domain-aligned architectures. Data mesh decentralizes data architecture by organizing data according to business domains, while API platforms productize business logic and processes. These initiatives advocate for cross-functional teams that manage long-lasting business domains autonomously, exposing business logic and data through APIs. The initiatives are linked by their shared objective of creating a self-service platform that aligns with business priorities, driving enterprise KPIs such as revenue, margin, and risk management. By aligning API and data mesh strategies, enterprises can synchronize their evolution, reduce duplicative efforts, and build a federated network of business domains supported by a central enablement team, ultimately enhancing their ability to deliver innovative and agile solutions.