Enterprises are prioritizing security best practices amid rising cybersecurity threats, with IT spending projected to increase, particularly in cloud computing and security software. A key trend in digital transformation is the transition from monolithic architectures to microservices, which presents unique security challenges due to a broader attack surface. Traditional security models are insufficient for microservices, necessitating a defense in depth (DiD) strategy that layers multiple protections. This approach encompasses physical, administrative, and technical controls, focusing on securing Kubernetes clusters and containerized microservices in the cloud. Key components include securing cloud accounts, Kubernetes clusters, containers, and code, complemented by tools like API gateways and service meshes to enhance security and offload responsibilities from developers. Kong Enterprise and Kong Mesh are highlighted as enterprise-ready solutions for implementing a robust DiD strategy, facilitating security in cloud-native environments through API management and secure service-to-service communication.