The Pharmome Map is a comprehensive public dataset created by EvE Bio, a non-profit organization under Convergent Research, that aims to transform drug-target interaction modeling by providing detailed measurements of drug activities across a wide range of potential protein targets. This mapping effort seeks to fill the gaps in understanding the effects of drugs on the human body, as pharmaceutical companies traditionally focus on single-target drug development without fully exploring off-target interactions. The dataset, the largest of its kind, is designed to support machine learning applications and includes high-throughput screening data for a library of 1,397 FDA-approved small molecule drugs against key drug target classes such as nuclear receptors, 7-transmembrane receptors (GPCRs), and protein kinases. These data are crucial for advancing fields like AE modeling, polypharmacology, and drug repurposing, offering insights into drug mechanisms, adverse events, and new therapeutic indications. The dataset is structured to include measures of compound activity and potency, and EvE Bio's ongoing work ensures continuous expansion, with new data added regularly, enhancing its utility for pharmacological research and drug development.