GitHub relies on MySQL to store its metadata, necessitating a sophisticated replication and failover strategy to ensure availability and manageability across multiple data centers. Orchestrator, an open-source MySQL replication management and high availability solution, is employed by GitHub to handle automated failovers and manage complex topologies. Orchestrator utilizes a holistic approach to failure detection by considering both the master and its replicas, ensuring minimal data loss and preventing unnecessary failovers. GitHub leverages Orchestrator's capabilities for topology management, allowing for seamless refactoring and management of nested replication topologies. The tool's integration with chatops enhances operational visibility and collaboration. Originally developed by Outbrain and further refined by Booking.com, Orchestrator continues to benefit from community contributions and is maintained as an open-source project under the Apache License 2.0.