The text discusses the challenges and solutions related to misinformation in large language models (LLMs), emphasizing the importance of developing a multi-layered defense strategy. It highlights the impact of misinformation, such as eroding trust and creating potential legal liabilities, especially in critical fields like healthcare and finance. The Open Worldwide Application Security Project (OWASP) now recognizes misinformation as a top security risk, necessitating a shift from traditional quality assurance methods to those that account for the probabilistic nature of LLMs. The proposed four-layer defense strategy includes ensuring high-quality, up-to-date data, aligning models to prioritize factuality, implementing autonomous evaluation systems for real-time misinformation detection, and employing production guardrails with compliance monitoring. The text further discusses the importance of using tools like Galileo, which combine autonomous factual assessment with real-time monitoring and intelligent guardrail protection, to maintain trustworthy AI systems at scale.