Man-in-the-middle (MitM) attacks pose a significant threat to web applications by allowing attackers to intercept, manipulate, or steal data exchanged between users and servers, often without detection. These attacks can lead to stolen credentials, account takeovers, financial fraud, and substantial reputational damage for organizations. Common techniques include SSL stripping, Wi-Fi hijacking, ARP spoofing, DNS spoofing, session hijacking, and SSL/TLS hijacking. Effective prevention strategies involve using TLS encryption, enforcing HTTPS with HSTS, certificate pinning, and DNS security, along with advanced detection methods like device intelligence to identify suspicious activities. By implementing layered defenses, organizations can significantly reduce the risk of MitM attacks, ensuring the protection of user data and maintaining trust.