In light of increasing stress levels and cybersecurity threats, CISOs in 2022 are encouraged to focus on five key priorities to maintain security and balance: adapting to complex hybrid work environments, accelerating the adoption of Zero Trust frameworks, automating security workflows, upskilling security teams, and preventing burnout. The transition to hybrid work presents unique security challenges, necessitating investments in cloud-based security solutions like extended detection and response (XDR). The Zero Trust framework, highlighted by President Biden's executive order, emphasizes a "trust nothing, record everything" approach, requiring security teams to scrutinize network access and products more closely. Automation is critical in managing complex security systems, freeing up human analysts for high-level threat analysis. Upskilling involves not only technical expertise but also business acumen and communication skills, as security professionals need to integrate seamlessly with management teams. Amidst these challenges, CISOs must ensure work-life balance for their teams and themselves to prevent burnout and maintain effectiveness in addressing the demands of a hybrid workforce.