Optimizing prompts for different Large Language Models (LLMs) is essential as each model, such as GPT-4, Claude, and Mistral, has unique behaviors and characteristics. Developers need to adapt prompts to maintain consistency, control costs, and efficiently utilize multi-model systems. Key strategies include understanding each model's behavior, using structured prompts, minimizing prompt length, adjusting for temperature and output variance, and testing output format consistency. Additionally, leveraging multi-model routing ensures the best model is used for each task, enhancing performance and stability. Continuous benchmarking and monitoring are crucial to keeping prompts effective, with tools like Eden AI facilitating seamless integration and management across multiple LLMs, thus reducing infrastructure challenges and empowering teams to focus on strategic prompt optimization.