Application security monitoring is a critical practice for managing the security of cloud-native and multicloud applications, especially as cloud complexity and software supply chain challenges grow. It involves continuously analyzing applications to identify vulnerabilities, detect threats, and mitigate attacks, offering organizations the ability to quickly respond to security incidents. The process includes identifying risks, detecting potential vulnerabilities, and ensuring timely remediation, with the use of tools like logging, vulnerability scanning, incident detection, and real-time monitoring. Best practices emphasize the importance of visibility, analytics, AI implementation, and staff involvement to optimize the monitoring process. Continuous monitoring helps organizations proactively prioritize vulnerabilities, enhance incident response, and fortify overall security. Modern solutions, such as those offered by Dynatrace, incorporate AI-driven tools and runtime analytics to efficiently manage vulnerabilities and risks, enabling organizations to maintain secure applications while fostering innovation.