The RSA 2022 guide highlights the importance of integrating DevSecOps practices to enhance application security and manage runtime vulnerabilities in multicloud environments. As organizations adopt cloud-native technologies, they face increased complexity and vulnerability exposure, necessitating a seamless approach to security. Traditional monitoring struggles to keep pace with the dynamic nature of modern IT environments, leading to blind spots that can threaten sensitive data. Automation and software intelligence, such as AIOps, are critical in addressing these challenges by enabling real-time observability and vulnerability management. The guide emphasizes the need for a modern approach to security that incorporates continual automation and AI to identify and remediate vulnerabilities more efficiently. Notable vulnerabilities like Log4Shell and Spring4Shell serve as reminders of the importance of proactive security measures. The guide underscores the role of DevSecOps in uniting development, security, and operations teams to create more secure software, with a focus on automation to ensure security without compromising speed and innovation.