Cloud Application Detection and Response (CADR) is a comprehensive approach to securing cloud-native environments by integrating visibility, analytics, and response into a unified platform. Dynatrace exemplifies CADR's effectiveness through its ability to detect and mitigate critical vulnerabilities, such as the Spring4Shell exploit, across multiple layers of application security. Spring4Shell, a remote code execution vulnerability in the Spring Framework, poses a significant threat due to its high criticality and ease of exploitation. Dynatrace's multi-layer defense includes Runtime Vulnerability Analytics, Security Posture Management, Threats & Exploits detection, and the Security Investigator, which collectively enable the identification, prevention, and investigation of exploits. By addressing vulnerabilities through configuration adjustments, monitoring for suspicious activities, and employing automated detection methods, Dynatrace helps organizations maintain robust security measures in cloud-native environments, ensuring the protection of applications against both known and unknown threats.