In a rapidly evolving digital landscape, zero-day vulnerabilities pose a significant threat to organizations as they exploit unknown flaws in software, leaving minimal time for mitigation. These vulnerabilities can become endemic, persisting as chronic issues over time. Traditional detection methods, such as behavior-based and statistics-based monitoring, often fall short in identifying new threats, which can lead to false positives or negatives. High-profile incidents like Log4Shell and Spring4Shell highlight the critical impact of zero-day vulnerabilities, as seen in the widespread exploitation attempts following their discovery. While conventional tools like web application firewalls and runtime application security protection have limitations, solutions like Dynatrace Application Security offer real-time protection by detecting and blocking attacks with code-level insights and transaction analysis. This approach ensures high accuracy and minimal false positives, providing a robust defense against these elusive threats.