Mean Time to Instrumentation (MTTI) is highlighted as a crucial factor in selecting modern Application Performance Monitoring (APM) tools, as articulated by an Enterprise Performance Engineer named Dustin. He underscores the need for MTTI to be reduced to two minutes due to the complexities of monitoring new-generation applications, such as cloud platforms and microservices, which demand rapid and efficient instrumentation. While second-generation APM tools like AppDynamics, NewRelic, and Dynatrace AppMon have reduced MTTI significantly from weeks to hours, they often require extensive knowledge of application environments, posing challenges in dynamic and diverse technological landscapes. Dustin advocates for automated configuration and enhanced default instrumentation to address these challenges, a sentiment echoed by Dynatrace's approach with its OneAgent, Smartscape, and PurePath technologies. These solutions offer seamless installation, full-stack visibility, and automated updates, leveraging AI to enhance monitoring efficiency and problem-solving, thereby aligning with modern DevOps and SRE team requirements.