Healthcare data collaboration faces significant challenges due to stringent privacy and security requirements, which complicate efforts despite the potential benefits. While the Health Information Portability and Privacy Act (HIPAA) establishes standards for protecting personal health information, it also necessitates complex data-sharing agreements and deidentification processes to ensure compliance. These processes, including anonymization and pseudonymization, often require specialized technology and expertise, posing financial and logistical burdens. The difficulty in balancing data utility with privacy concerns is evident, as deidentification can reduce data accuracy and hinder insights. Additionally, different state laws and the involvement of various teams with divergent priorities further complicate the coordination needed for effective data sharing. The text highlights that while mergers and acquisitions in healthcare aim to centralize data ownership to streamline processes, they do not entirely resolve the technical and regulatory hurdles that persist.