Maximizing productivity in VS Code can be achieved by mastering essential keyboard shortcuts, which help minimize disruptions caused by frequent switching between the keyboard and mouse. These shortcuts enable quick navigation, customization, and efficient code editing within the editor. Key functions include Quick Open for rapid file access, the Command Palette for executing various commands, multi-cursor editing for simultaneous line changes, and powerful find-and-replace capabilities. Additional shortcuts enhance workflow by toggling the sidebar for more coding space, accessing definitions directly, splitting the editor for side-by-side file viewing, and opening an integrated terminal for seamless command-line operations. Commenting lines, and renaming symbols across projects streamline coding tasks, making these shortcuts indispensable for developers working in VS Code.