The guide outlines the process of setting up Daytona, a development environment tool, with a remote machine. It begins by installing Daytona on a local machine and verifying its installation. The next steps involve preparing a remote machine for use with Daytona, adding the remote machine as a target in Daytona, integrating Git providers, creating and accessing a workspace, and opening the workspace in VS Code. Throughout the process, users are guided through various commands and configurations to ensure seamless integration of their development environment.