Comprehensive monitoring of ActiveMQ, both Classic and Artemis, can be achieved by integrating it with Datadog to track performance metrics, logs, and alerts for potential issues. This involves configuring ActiveMQ to send metrics to Datadog via JMX and the Web Console, installing the Datadog Agent, and customizing dashboards to visualize metrics. By enabling log collection and using custom tags, users can correlate logs with metrics to analyze trends and troubleshoot issues effectively. Datadog's alert system can be tailored using tags to maintain awareness of critical issues, and integration with various notification services ensures timely communication with teams. The article provides detailed instructions for setting up these monitoring capabilities, emphasizing the importance of visibility into the entire messaging infrastructure.