The MEAN stack is a popular choice for developing dynamic applications. It bundles together complementary technologies, including MongoDB, Express, Angular, and Node.js. Datadog provides comprehensive monitoring capabilities for the MEAN stack, enabling developers to gain deeper insights into application performance, logs, and infrastructure. The guide covers installing and configuring the Datadog Agent, enabling integrations with MongoDB, Express, and Node.js, and instrumenting applications with Datadog APM. With Datadog's 850+ integrations, users can monitor their MEAN stack alongside other services running in their infrastructure.