The OpenTelemetry project merges the OpenTracing and OpenCensus projects to provide a standard set of APIs, libraries, and tools for capturing distributed request traces and metrics from applications and exporting them to third-party monitoring platforms. Datadog is supporting this project and building on it to provide out-of-the-box instrumentation for Python applications using OpenTelemetry's suite of tools and its existing tracing libraries. The new Python exporter for sending traces from instrumented Python applications to Datadog enables seamless integration with other applications already instrumented with either OpenTelemetry or Datadog libraries, allowing developers to easily plug in any exporter without changing their instrumentation. This guide shows how to instrument a basic Python application with OpenTelemetry and how to plug in the new Python exporter to start collecting data, as well as how to instrument a Flask application with Datadog and OpenTelemetry, visualizing distributed traces in Datadog, and starting to instrument with OpenTelemetry and Datadog today.