WebRTC development can be tricky, especially when setting up a local machine environment for video calls. To load pages securely, use https URLs or http://localhost as an exception to the rule. Testing first on Chrome is recommended due to its mature WebRTC support, and using ngrok to create HTTPS tunnels can help test actual video calls with multiple participants. Additionally, setting the allow property in iframes is necessary for WebRTC code running inside an iframe, and testing mic, camera, and network on a known-working site like webrtc.org can help troubleshoot issues.