When considering the choice between GraphQL and REST, it's essential to evaluate your specific constraints and needs. GraphQL is ideal for applications that require granular control over data retrieval, such as when dealing with complex or interconnected data. It provides a self-documenting schema and type-safe queries, allowing developers to specify exactly what information they need. However, GraphQL also comes with its own set of challenges, including a steep learning curve, control inversion, and potential naming collisions. REST, on the other hand, is a familiar option that can be implemented quickly, with many ORMs optimized for it. It's well-suited for quick transactional requests and shares complexity between client and server. Ultimately, the choice between GraphQL and REST depends on your specific use case and needs, requiring careful consideration of trade-offs and potential challenges.