Anti-virus software can sometimes hinder the use of Couchbase, a distributed NoSQL document database, by blocking installations, known ports, or mistakenly flagging code as malware. These issues arise due to aggressive heuristics, outdated virus definitions, or misclassifications under the Potentially Unwanted Application (PUA) category. To mitigate these challenges, Couchbase scans its binaries with popular antivirus scanners to ensure they are virus-free, and suggests verifying software safety through multiple scanners to confirm if detections are false positives. Users are encouraged to report false positives to their antivirus vendors to facilitate future whitelisting. Tools like VirusTotal are recommended for scanning files and URLs to detect malicious content and false positives. Additionally, users should verify the integrity of downloads and ensure antivirus settings do not block necessary ports for Couchbase's operation while adhering to its security best practices.