Testing a new AI assistant has revealed that while it can handle 90% of user prompts effectively, it sometimes provides incorrect answers that appear convincing but are fundamentally wrong, such as unsafe medical advice or inaccurate legal summaries. The human-in-the-loop (HITL) feedback approach is crucial in these scenarios, embedding humans at critical points in the AI lifecycle to review outputs, correct errors, and guide system behavior. This approach is essential because LLMs can make confident mistakes due to their probabilistic nature, often generating outputs that lack actual grounding. HITL helps address LLM limitations such as hallucinations, ambiguity, and edge cases, ensuring outputs are not only factually correct but aligned with domain-specific nuances, business intents, and user experiences. Human feedback is vital for maintaining ethical standards, regulatory compliance, and brand reputation, as humans can navigate complex scenarios and policy changes that models may not handle well. To operationalize HITL effectively, teams use strategies like Reinforcement Learning from Human Feedback, Active Learning, and Interactive Machine Learning, which involve structured reviews and iterative feedback loops to refine AI outputs. Tools like Opik support these processes by providing a detailed trace of AI activity and enabling cross-functional collaboration, ensuring AI systems are continuously improved and aligned with organizational goals and standards.