The article provides a detailed step-by-step guide on deploying and securing a multi-cluster CockroachDB setup using the Calico clustermesh, focusing on achieving scalable and secure inter-cluster communication across multiple regions. It highlights the challenges of deploying persistent workloads like databases in Kubernetes, particularly in a multi-region context, and how CockroachDB, with its distributed architecture and strong consistency guarantees, is well-suited for these use cases. The guide outlines the process of setting up a multi-region AWS network, provisioning Kubernetes clusters, enabling pod communication, deploying CockroachDB, and securing its deployment through Calico Cloud's federated endpoints identity. Ultimately, it emphasizes the importance of Calico's clustermesh in facilitating efficient cross-cluster communication and policy enforcement, thereby addressing the complexities of a multi-cluster network architecture and enhancing scalability and security for global applications.