In the 2022 Cloud Report, AMD's Milan processors emerged as the top performers for OLTP workloads across leading public cloud providers AWS, GCP, and Azure, demonstrating superior performance and cost-efficiency compared to Intel's offerings. The report utilized a variation of the TPC-C benchmark to assess OLTP performance and CoreMark for direct CPU performance metrics, highlighting that AMD Milan processors consistently outperformed, securing the top spots in both performance and price-for-performance categories. Despite AMD's dominance, Intel's latest-generation processors, particularly the Cascade Lake series, remained highly competitive, emphasizing that the choice of CPU may vary based on specific workload requirements. The report provides extensive analysis and insights across 56 different instance types, including considerations for storage and network performance, offering readers a comprehensive guide to selecting the optimal instance type for their needs.