The 2022 Cloud Report offers a comprehensive analysis of cloud performance, featuring results from over 3,000 OLTP test runs across 56 instance types on AWS, GCP, and Azure, highlighting AMD's Milan CPUs outperforming Intel for the first time in terms of both performance and cost-effectiveness. This year's report, which is more extensive than previous editions, includes testing of a wider range of instance configurations, node sizes, and increased test durations, aiming to provide a deeper understanding of performance variations with workload complexities. The report introduces the Cockroach Labs Derivative TPC-C nowait benchmark, which modifies the traditional TPC-C benchmark to better compare instance types by removing wait times, thus focusing on pure transactional throughput. The 2022 edition emphasizes realism in simulation and provides detailed insights into various cloud configurations, remaining a free resource for those interested in cloud performance metrics.