The 2023 predictions for DevOps and Software Supply Chain Security discussed in the webinar include reducing toolchain complexity, making SBOMs (Software Bill of Materials) more useful and actionable, prioritizing developer experience and productivity, and addressing distributed engineering teams. The conversation also touches on platform engineering versus DevOps, software bill of materials, and how to make them actionable and easy for developers to use. The panelists emphasize the importance of security, compliance, and governance in the development process, with a focus on making it more efficient and user-friendly for developers.