The Cloudsmith Command Line Interface (CLI) is a Python-based tool that enables automation and first-class command line tooling for Cloudsmith users. The CLI can be installed using pip and requires configuration with the `cloudsmith login` command to retrieve an API key and set up credentials. It supports various package formats, including npm, Python, Cargo, Debian, and Maven, with additional requirements for some formats. The CLI provides a simple and easy-to-use interface for common tasks such as uploading packages, listing repository contents, and retrieving entitlement tokens. Resources are available for further assistance, including documentation, a GitHub repository, and pre-releases of the CLI.