Nacho Iacovino, the Developer Advocate at Clerk, provides a comprehensive guide on deploying Clerk using Vercel, emphasizing its simplicity and speed for setting up applications with built-in auth features. The process involves creating an account on Clerk, starting a project with Next.js and Vercel, and integrating Clerk for authentication. Users are guided through creating a GitHub repository and deploying the project on Vercel, which automatically sets the necessary environment variables. The tutorial also covers cloning the repository locally, running the application, and exploring its features. Users can configure user management and theme settings through Clerk's dashboard, with distinct instances for development, staging, and production environments, allowing for customization without altering code or redeploying. The guide encourages users to explore different configurations and offers support for any issues encountered.