Large Language Models (LLMs) are revolutionizing natural language processing but face challenges related to inference efficiency, impacting cost and time. Research efforts have focused on optimizing caching, memory usage, and GPU performance to mitigate these issues. Notable open-source frameworks like vLLM, LMDeploy, and SGLang stand out for their distinct approaches to improving LLM performance. vLLM enhances memory efficiency and parallel computation, LMDeploy simplifies large-scale deployment with model parallelism, and SGLang employs structured programming for efficient resource management. Benchmarks show SGLang excels in handling single requests but struggles with certain architectures under concurrent loads, while LMDeploy consistently leads in throughput for both single and multiple requests. TGI faces stability issues with Out-Of-Memory errors in specific scenarios. Clarifai offers tools for deploying and managing models across various environments, focusing on performance, cost, and security.