GPU acceleration is essential for modern AI, but it often incurs significant costs due to high hourly rates and underutilized resources. To manage these expenses effectively, companies need a comprehensive strategy beyond basic tips. This guide offers a range of solutions, such as rightsizing hardware, using spot instances, and applying model-level optimizations to reduce GPU costs while maintaining performance. Clarifai's Compute Orchestration and Reasoning Engine help maximize efficiency by dynamically scheduling workloads and facilitating high throughput in inference tasks. Additionally, emerging trends like serverless GPUs, decentralized networks, and energy-efficient hardware provide new opportunities for cost savings. By adopting these strategies, organizations can achieve substantial cost reductions and improve the agility and sustainability of their AI operations.