USD Coin (USDC) plays a pivotal role in the Ethereum ecosystem, particularly in decentralized applications (dApps) and decentralized finance (DeFi) protocols, offering a secure and stable medium for transactions. USDC is accessible through various digital asset exchanges, with Ethereum being the blockchain with the most USDC circulation as of March 2023. Businesses can obtain USDC ERC20, the Ethereum-specific variant, by purchasing it with fiat currencies or exchanging other cryptocurrencies on compatible platforms like Coinbase, Kraken, and KuCoin. It is crucial to use ERC20-compatible wallets to avoid compatibility issues, as USDC is a multi-chain asset issued on different blockchains. USDC is extensively integrated into Ethereum's DeFi projects, such as Aave, Uniswap, and Compound, and is popular in the NFT marketplaces like OpenSea due to its stability compared to other volatile digital assets.